1、GPQGIWGQ
单字母 H2N-GPQGIWGQ-OH
多字母 H2N-Gly-Pro-Gln-Gly-Ile-Trp-Gly-Gln-OH
氨基酸个数 8
分子式 C38H55N11O11
平均分子量(MW) 841.91
参考文献：Ferreira, D. S. et al. Molecularly engineered self-assembling membranes for cell-mediated degradation. Adv. Healthc. Mater. 4, 602–612 (2015).
2、VPMSMRGG
单字母 H2N-VPMSMRGG-OH
多字母 H2N-Val-Pro-Met-Ser-Met-Arg-Gly-Gly-OH
氨基酸个数 8
分子式 C33H59N11O10S2
平均分子量(MW) 834.02
参考文献：Patterson, J. & Hubbell, J. A. Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. Biomaterials 31, 7836–7845 (2010).
3、IPESLRAG
单字母 H2N-IPESLRAG-OH
多字母 H2N-Ile-Pro-Glu-Ser-Leu-Arg-Ala-Gly-OH
氨基酸个数 8
分子式 C36H63N11O12
平均分子量(MW) 841.95
参考文献：Patterson, J. & Hubbell, J. A. Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. Biomaterials 31, 7836–7845 (2010).
能够被基质金属蛋白酶-2（MMP-2）切割的多肽序列
1、GTAGLIGQ
单字母 H2N-GTAGLIGQ-OH
多字母 H2N-Gly-Thr-Ala-Gly-Leu-Ile-Gly-Gln-OH
氨基酸个数 8
分子式 C30H53N9O11
平均分子量(MW) 715.8
参考文献：Kim, J.-K., Anderson, J., Jun, H.-W., Repka, M. A. & Jo, S. Self-assembling peptide amphiphile-based nanofiber gel for bioresponsive cisplatin delivery. Mol. Pharm. 6, 978–985 (2009).
2、PVGLIG
单字母 H2N-PVGLIG-OH
多字母 H2N-Pro-Val-Gly-Leu-Ile-Gly-OH
氨基酸个数 6
分子式 C26H46N6O7
平均分子量(MW) 554.68
参考文献：Chau, Y. et al. Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides — a model for biofunctional scaffolds. Biomaterials 29, 1713–1719 (2008).
3、SLGK
单字母 H2N-SLGK-OH
多字母 H2N-Ser-Leu-Gly-Lys-OH
氨基酸个数 4
分子式 C17H33N5O6
平均分子量(MW) 403.47
参考文献：Chen, C. et al. Rational design of short peptide-based hydrogels with MMP-2 responsiveness for controlled anticancer peptide delivery. Biomacromolecules 18, 3563–3571 (2017).
4、LDLPVGLIGKLD
单字母 H2N-LDLPVGLIGKLD-OH
多字母 H2N-Leu-Asp-Leu-Pro-Val-Gly-Leu-Ile-Gly-Lys-Leu-Asp-OH
氨基酸个数 12
分子式 C58H101N13O17
平均分子量(MW) 1252.5
参考文献：Zhou, Y. et al. Injectable extracellular vesicle-released self-assembling peptide nanofiber hydrogel as an enhanced cell-free therapy for tissue regeneration. J. Control. Rel. 316, 93–104 (2019).
5、GPQGIAGQ
单字母 H2N-GPQGIAGQ-OH
多字母 H2N-Gly-Pro-Gln-Gly-Ile-Ala-Gly-Gln-OH
氨基酸个数 8
分子式 C30H50N10O11
平均分子量(MW) 726.78
参考文献：Lin, Y.-A., Ou, Y.-C., Cheetham, A. G. & Cui, H. Rational design of MMP degradable peptide-based supramolecular filaments. Biomacromolecules 15, 1419–1427 (2014).
6、IPVSLRSG
单字母 H2N-IPVSLRSG-OH
多字母 H2N-Ile-Pro-Val-Ser-Leu-Arg-Ser-Gly-OH
氨基酸个数 8
分子式 C36H65N11O11
平均分子量(MW) 827.97
参考文献：Lin, Y.-A., Ou, Y.-C., Cheetham, A. G. & Cui, H. Rational design of MMP degradable peptide-based supramolecular filaments. Biomacromolecules 15, 1419–1427 (2014).
7、SGESPAYYTA
单字母 H2N-SGESPAYYTA-OH
多字母 H2N-Ser-Gly-Glu-Ser-Pro-Ala-Tyr-Tyr-Thr-Ala-OH
氨基酸个数 10
分子式 C46H64N10O18
平均分子量(MW) 1045.06
参考文献：Chen, E. I. et al. A unique substrate recognition profile for matrix metalloproteinase-2. J. Biol. Chem. 277, 4485–4491 (2002).
8、VPMSMRGG
单字母 H2N-VPMSMRGG-OH
多字母 H2N-Val-Pro-Met-Ser-Met-Arg-Gly-Gly-OH
氨基酸个数 8
分子式 C33H59N11O10S2
平均分子量(MW) 834.02
参考文献：Patterson, J. & Hubbell, J. A. Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. Biomaterials 31, 7836–7845 (2010).
9、IPESLRAG
单字母 H2N-IPESLRAG-OH
多字母 H2N-Ile-Pro-Glu-Ser-Leu-Arg-Ala-Gly-OH
氨基酸个数 8
分子式 C36H63N11O12
平均分子量(MW) 841.95
参考文献：Patterson, J. & Hubbell, J. A. Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. Biomaterials 31, 7836–7845 (2010).
能够被基质金属蛋白酶-3（MMP-3）切割的多肽序列
1、GAPFALRLV
单字母 H2N-GAPFALRLV-OH
多字母 H2N-Gly-Ala-Pro-Phe-Ala-Leu-Arg-Leu-Val-OH
氨基酸个数 9
分子式 C45H74N12O10
平均分子量(MW) 943.14
参考文献：Smith, M. M., Shi, L. & Navre, M. Rapid identification of highly active and selective substrates for stromelysin and matrilysin using bacteriophage peptide display libraries. J. Biol. Chem. 270, 6440–6449 (1995).
能够被基质金属蛋白酶-7（MMP-7）切割的多肽序列
1、GAPFALRLV
单字母 H2N-GAPFALRLV-OH
多字母 H2N-Gly-Ala-Pro-Phe-Ala-Leu-Arg-Leu-Val-OH
氨基酸个数 9
分子式 C45H74N12O10
平均分子量(MW) 943.14
参考文献：Smith, M. M., Shi, L. & Navre, M. Rapid identification of highly active and selective substrates for stromelysin and matrilysin using bacteriophage peptide display libraries. J. Biol. Chem. 270, 6440–6449 (1995).
能够被基质金属蛋白酶-9（MMP-9）切割的多肽序列
1、FFAGLDD
单字母 H2N-FFAGLDD-OH
多字母 H2N-Phe-Phe-Ala-Gly-Leu-Asp-Asp-OH
氨基酸个数 7
分子式 C37H49N7O12
平均分子量(MW) 783.82
参考文献：Kalafatovic, D. et al. MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomater. Sci. 3, 246–249 (2015).
2、PLGL
单字母 H2N-PLGL-OH
多字母 H2N-Pro-Leu-Gly-Leu-OH
氨基酸个数 4
分子式 C19H34N4O5
平均分子量(MW) 398.5
参考文献：Adak, A. et al. Extracellular matrix (ECM)-mimicking neuroprotective injectable sulfo-functionalized peptide hydrogel for repairing brain injury. ACS Biomater. Sci. Eng. 6, 2287–2296 (2020).
能够被基质金属蛋白酶-11（MMP-11）切割的多肽序列
1、GGYAELRMGG
单字母 H2N-GGYAELRMGG-OH
多字母 H2N-Gly-Gly-Tyr-Ala-Glu-Leu-Arg-Met-Gly-Gly-OH
氨基酸个数 10
分子式 C42H67N13O14S1
平均分子量(MW) 1010.13
参考文献：Pan, W. et al. Identification of peptide substrates for human MMP-11 (stromelysin-3) using phage display. J. Biol. Chem. 278, 27820–27827 (2003).
能够被基质金属蛋白酶-13（MMP-13）切割的多肽序列
1、PTG-XKV (X=l, L, F, A)
单字母 H2N-PTGAKV-OH
多字母 H2N-Pro-Thr-Gly-Ala-Lys-Val-OH
氨基酸个数 6
分子式 C25H45N7O8
平均分子量(MW) 571.67
参考文献：Giano, M. C., Pochan, D. J. & Schneider, J. P. Controlled biodegradation of self-assembling β-hairpin peptide hydrogels by proteolysis with matrix metalloproteinase-13. Biomaterials 32, 6471–6477 (2011).
2、GPLGYLWAR
单字母 H2N-GPLGYLWAR-OH
多字母 H2N-Gly-Pro-Leu-Gly-Tyr-Leu-Trp-Ala-Arg-OH
氨基酸个数 9
分子式 C50H73N13O11
平均分子量(MW) 1032.2
参考文献：Deng, S. J. et al. Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library. J. Biol. Chem. 275, 31422–31427 (2000).
3、GPLGMRGL
单字母 H2N-GPLGMRGL-OH
多字母 H2N-Gly-Pro-Leu-Gly-Met-Arg-Gly-Leu-OH
氨基酸个数 8
分子式 C34H61N11O9S1
平均分子量(MW) 799.98
参考文献：Deng, S. J. et al. Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library. J. Biol. Chem. 275, 31422–31427 (2000).
参考文献：doi.org/10.1038/s44222-023-00055-3
