34种治疗口腔感染的抗菌肽-合肥肽库生物科技有限公司官网-多肽定制-多肽合成公司

34种治疗口腔感染的抗菌肽

浏览量：195 ｜ 2026/7/15 9:59:40

为应对细菌感染与口腔癌之间复杂的相互关系，抗菌肽（AMPs）成为一种有前景的解决途径。目前已有超过100种基于肽的药物获得美国食品药品监督管理局（FDA）批准，而治疗性肽类药物市场的预测显示其将实现显著增长。肽分子在许多生物体中发挥着重要的生理和生化作用，具有多种功能，如神经调节剂、神经递质和激素等。此外，肽还参与代谢、生殖以及免疫应答等过程。在肽所表现出的多种生物学活性中，其抗菌功能尤为引人注目。抗菌肽通常为带正电荷的多肽，对细菌、真菌、寄生虫和病毒均具有抗菌活性。它们通过破坏微生物膜、干扰细胞内过程以及调节宿主免疫反应来发挥抗菌作用。除了抗菌特性外，许多抗菌肽还表现出抗癌活性。这些肽类通过多种机制发挥作用，例如破坏细胞膜、引起DNA损伤、抑制血管生成、调节免疫细胞/调控免疫反应，以及干扰细胞增殖/细胞周期调控。某些抗菌肽同时具备抗菌和抗肿瘤活性，使其成为治疗口腔癌及感染的极具吸引力的候选药物。

我们文献检索旨在筛选出对牙龈卟啉单胞菌和/或具核梭杆菌具有活性的抗菌肽，这两种细菌是与致癌相关的口腔主要病原体。整理的多肽序列及参考文献如下：

1、DP7

单字母 H2N-VQWRIRVAVIRK-OH

多字母 H2N-Val-Gln-Trp-Arg-Ile-Arg-Val-Ala-Val-Ile-Arg-Lys-OH

氨基酸个数 12

分子式 C70H122N24O14

平均分子量(MW) 1523.87

参考文献：JiangSJXiaoXZhengJLaiSYangLLiJet al. Antibacterial and antibiofilm activities of novel antimicrobial peptide DP7 against the periodontal pathogen Porphyromonas gingivalis. J Appl Microbiol. (2022) 133:1052–62. doi: 10.1111/jam.15614

2、Pep-7

单字母 H2N-RPHGAGEGIDRVPAGPSPSEVGLAIPSGK-OH

多字母 H2N-Arg-Pro-His-Gly-Ala-Gly-Glu-Gly-Ile-Asp-Arg-Val-Pro-Ala-Gly-Pro-Ser-Pro-Ser-Glu-Val-Gly-Leu-Ala-Ile-Pro-Ser-Gly-Lys-OH

氨基酸个数 29

分子式 C121H198N38O39

平均分子量(MW) 2809.1

参考文献：SuwandechaTSrichanaTBalekarNNakphengTPangsomboonK. Novel antimicrobial peptide specifically active against Porphyromonas gingivalis. Arch Microbiol. (2015) 197:899–909. doi: 10.1007/s00203-015-1126-z,

3、Amyl-1-18

单字母 H2N-HLNKRVQRELIGWLDWLK-OH

多字母 H2N-His-Leu-Asn-Lys-Arg-Val-Gln-Arg-Glu-Leu-Ile-Gly-Trp-Leu-Asp-Trp-Leu-Lys-OH

氨基酸个数 18

分子式 C107H170N32O25

平均分子量(MW) 2304.69

参考文献：TaniguchiMOchiaiATakahashiKNakamichiSINomotoTSaitohEet al. Antimicrobial activity and mechanism of action of a novel cationic α-helical octadecapeptide derived from α-amylase of rice. Biopolymers. (2015) 104:73–83. doi: 10.1002/bip.22605,

4、Microcin C7

单字母 H2N-MRTGNAD-OH

多字母 H2N-Met-Arg-Thr-Gly-Asn-Ala-Asp-OH

氨基酸个数 7

分子式 C28H49N11O12S1

平均分子量(MW) 763.82

参考文献：ZhouSMiaoDWenJZhangQHuDLiuNet al. Microcin C7-laden modified gelatin based biocomposite hydrogel for the treatment of periodontitis. Int J Biol Macromol. (2024) 258:128293. doi: 10.1016/j.ijbiomac.2023.128293,

5、TPS-032

单字母 H2N-RVLTHVFKCKLKLR-OH

多字母 H2N-Arg-Val-Leu-Thr-His-Val-Phe-Lys-Cys-Lys-Leu-Lys-Leu-Arg-OH

氨基酸个数 14

分子式 C80H141N25O16S1

平均分子量(MW) 1741.2

参考文献：LeeKWKimJGVeerappanKChungHNatarajanSKimKYet al. Utilizing red spotted apollo butterfly transcriptome to identify antimicrobial peptide candidates against Porphyromonas gingivalis. Insects. (2021) 12:466. doi: 10.3390/insects12050466,

6、Nisin z

单字母 H2N-ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK-OH

多字母 H2N-Ile-Thr-Ser-Ile-Ser-Leu-Cys-Thr-Pro-Gly-Cys-Lys-Thr-Gly-Ala-Leu-Met-Gly-Cys-Asn-Met-Lys-Thr-Ala-Thr-Cys-Asn-Cys-Ser-Ile-His-Val-Ser-Lys-OH

氨基酸个数 34

分子式 C141H245N41O46S7

平均分子量(MW) 3475.16

参考文献：ShinJMAteiaIPaulusJRLiuHFennoJCRickardAHet al. Antimicrobial nisin acts against saliva derived multi-species biofilms without cytotoxicity to human oral cells. Front Microbiol. (2015) 6:617. doi: 10.3389/fmicb.2015.00617,

7、K4-S4 (1-15)a

单字母 H2N-LWKTLLKKVLKAAA-CONH2

多字母 H2N-Leu-Trp-Lys-Thr-Leu-Leu-Lys-Lys-Val-Leu-Lys-Ala-Ala-Ala-CONH2

氨基酸个数 14

分子式 C77H136N20O15

平均分子量(MW) 1582.03

参考文献：AltmanHSteinbergDPoratYMorAFridmanDFriedmanMet al. In vitro assessment of antimicrobial peptides as potential agents against several oral bacteria. J Antimicrob Chemother. (2006) 58:198–201. doi: 10.1093/jac/dkl181,

8、Dhvar4a

单字母 H2N-KRLFKKLLFSLRKY-CONH2

多字母 H2N-Lys-Arg-Leu-Phe-Lys-Lys-Leu-Leu-Phe-Ser-Leu-Arg-Lys-Tyr-CONH2

氨基酸个数 14

分子式 C90H151N25O16

平均分子量(MW) 1839.32

9、SCPPPQ1

单字母 H2N-FPLPPQPP-OH

多字母 H2N-Phe-Pro-Leu-Pro-Pro-Gln-Pro-Pro-OH

氨基酸个数 8

分子式 C45H65N9O10

平均分子量(MW) 892.05

参考文献：MaryCFouillenAMoffattPGuadarrama BelloDWazenRMGrenierDet al. Effect of human secretory calcium-binding phosphoprotein proline-glutamine rich 1 protein on Porphyromonas gingivalis and identification of its active portions. Sci Rep. (2021) 11:1–14. doi: 10.1038/s41598-021-02661-w,

10、Br-J-I

单字母 H2N-PFaKLSLHL-CONH2

多字母 H2N-Pro-Phe-DAla-Lys-Leu-Ser-Leu-His-Leu-CONH2

氨基酸个数 9

分子式 C50H81N13O10

平均分子量(MW) 1024.26

参考文献：JiaFYuQWangRZhaoLYuanFGuoHet al. Optimized antimicrobial peptide Jelleine-I derivative Br-J-I inhibits Fusobacterium Nucleatum to suppress colorectal Cancer progression. Int J Mol Sci. (2023) 24:1469. doi: 10.3390/ijms24021469,

11、LL37f

单字母 H2N-KRIVQRIKDFLRNLVPRTES-OH

多字母 H2N-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH

氨基酸个数 20

分子式 C109H190N36O29

平均分子量(MW) 2468.9

参考文献：ConsuegraJElena de LimaMSantosDSinisterraRDCortésME. Peptides: β-Cyclodextrin inclusion compounds as highly effective antimicrobial and anti-epithelial proliferation agents. J Periodontol. (2013) 84:1858–68. doi: 10.1902/jop.2013.120679,

12、KR12

单字母 H2N-KRIVQRIKDFLR-OH

多字母 H2N-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-OH

氨基酸个数 12

分子式 C71H126N24O16

平均分子量(MW) 1571.91

13、LyeTxI

单字母 H2N-IWLTALKFLGKNLGKHLAKQQLAKL-OH

多字母 H2N-Ile-Trp-Leu-Thr-Ala-Leu-Lys-Phe-Leu-Gly-Lys-Asn-Leu-Gly-Lys-His-Leu-Ala-Lys-Gln-Gln-Leu-Ala-Lys-Leu-OH

氨基酸个数 25

分子式 C135H226N36O30

平均分子量(MW) 2833.46

14、κ-casein (109–137)

单字母 H2N-PPKKNQDKTEIPTINTIASGEPTSTPTTE-OH

多字母 H2N-Pro-Pro-Lys-Lys-Asn-Gln-Asp-Lys-Thr-Glu-Ile-Pro-Thr-Ile-Asn-Thr-Ile-Ala-Ser-Gly-Glu-Pro-Thr-Ser-Thr-Pro-Thr-Thr-Glu-OH

氨基酸个数 29

分子式 C132H219N35O50

平均分子量(MW) 3096.36

参考文献：TohECYDashperSGHuqNLAttardTJO’Brien-SimpsonNMChenYYet al. Porphyromonas gingivalis cysteine proteinase inhibition by κ-casein peptides. Antimicrob Agents Chemother. (2010) 55:1155–61. doi: 10.1128/AAC.00466-10,

15、Nal-P-113

单字母 Ac-AKR-2Nal-2Nal-GYKRKF-2Nal-CONH2

多字母 Ac-Ala-Lys-Arg-2Nal-2Nal-Gly-Tyr-Lys-Arg-Lys-Phe-2Nal-CONH2

氨基酸个数 12

分子式 C94H124O14N22

平均分子量(MW) 1786.13

参考文献：WangHYChengJWYuHYLinLChihYHPanYP. Efficacy of a novel antimicrobial peptide against periodontal pathogens in both planktonic and polymicrobial biofilm states. Acta Biomater. (2015) 25:150–61. doi: 10.1016/j.actbio.2015.07.031,

16、LL-31

单字母 H2N-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNL-OH

多字母 H2N-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-OH

氨基酸个数 31

分子式 C177H293N51O43

平均分子量(MW) 3823.54

参考文献：SoldatiKRJiangYBrandtBWExterkateRAMBuijsMJNazmiKet al. Differential modulation of saliva-derived microcosm biofilms by antimicrobial peptide LL-31 and D-LL-31. Pathogens. (2023) 12:1295. doi: 10.3390/pathogens12111295,

17、hCAP (109–135)

单字母 H2N-FRKSKEKIGKEFKRIVQRIKDFLRNLV-OH

多字母 H2N-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-OH

氨基酸个数 27

分子式 C155H263N47O37

平均分子量(MW) 3377.04

参考文献：IsogaiEIsogaiHMatuoKHiroseKKowashiYOkumuaraKet al. Sensitivity of genera Porphyromonas and Prevotella to the bactericidal action of C-terminal domain of human CAP18 and its analogues. Oral Microbiol Immunol. (2003) 18:329–32. doi: 10.1034/j.1399-302X.2003.00083.x,

18、Glycinin-17

单字母 H2N-RKSREWRSKKTQPRRPR-OH

多字母 H2N-Arg-Lys-Ser-Arg-Glu-Trp-Arg-Ser-Lys-Lys-Thr-Gln-Pro-Arg-Arg-Pro-Arg-OH

氨基酸个数 17

分子式 C95H166N40O24

平均分子量(MW) 2252.59

参考文献：TaniguchiMSaitoKNomotoTNamaeTOchiaiASaitohEet al. Identification and characterization of multifunctional cationic and amphipathic peptides from soybean proteins. Peptide Sci. (2017) 108:e23023. doi: 10.1002/bip.23023,

19、BCAS-16

单字母 H2N-KNQYGRIRVLQRFNQR-OH

多字母 H2N-Lys-Asn-Gln-Tyr-Gly-Arg-Ile-Arg-Val-Leu-Gln-Arg-Phe-Asn-Gln-Arg-OH

氨基酸个数 16

分子式 C90H150N34O23

平均分子量(MW) 2076.37

20、BCBS-11

单字母 H2N-RIRLLQRFNKR-OH

多字母 H2N-Arg-Ile-Arg-Leu-Leu-Gln-Arg-Phe-Asn-Lys-Arg-OH

氨基酸个数 11

分子式 C66H118N26O14

平均分子量(MW) 1499.81

21、Plantaricin 149

单字母 H2N-YSLQMGATAIKQVKKLFKKKGG-OH

多字母 H2N-Tyr-Ser-Leu-Gln-Met-Gly-Ala-Thr-Ala-Ile-Lys-Gln-Val-Lys-Lys-Leu-Phe-Lys-Lys-Lys-Gly-Gly-OH

氨基酸个数 22

分子式 C111H190N30O28S1

平均分子量(MW) 2424.95

参考文献：WangYChenKLinX. Comparison of antibacterial effect of plantaricin 149 suspension and traditional root canal irrigation solutions in root canal infections in vitro. BMC Oral Health. (2022) 22:643–7. doi: 10.1186/s12903-022-02683-4,

22、Hsp-70 (241–258)

单字母 H2N-DNRMVNHFVQEFKRHKK-OH

多字母 H2N-Asp-Asn-Arg-Met-Val-Asn-His-Phe-Val-Gln-Glu-Phe-Lys-Arg-His-Lys-Lys-OH

氨基酸个数 17

分子式 C97H153N33O25S1

平均分子量(MW) 2213.52

参考文献：TaniguchiMIkedaANakamichiSIIshiyamaYSaitohEKatoTet al. Antimicrobial activity and mechanism of action of a novel cationic α-helical octadecapeptide derived from heat shock protein 70 of rice. Peptides (NY). (2013) 48:147–55. doi: 10.1016/j.peptides.2013.08.011,

23、MUC7-12-mer-D

单字母 H2N-RKSYKCLHKRCR-OH

多字母 H2N-Arg-Lys-Ser-Tyr-Lys-Cys-Leu-His-Lys-Arg-Cys-Arg-OH

氨基酸个数 12

分子式 C66H116N26O15S2

平均分子量(MW) 1577.92

参考文献：WeiGXCampagnaANBobekLA. Effect of MUC7 peptides on the growth of bacteria and on Streptococcus mutans biofilm. J Antimicrob Chemother. (2006) 57:1100–9. doi: 10.1093/jac/dkl120,

24、CL (14–25)

单字母 H2N-RRLMAAKAESRK-OH

多字母 H2N-Arg-Arg-Leu-Met-Ala-Ala-Lys-Ala-Glu-Ser-Arg-Lys-OH

氨基酸个数 12

分子式 C58H109N23O16S1

平均分子量(MW) 1416.7

参考文献：TaniguchiMYoshiyasuMAbeTKIshiyamaYEiichiSKatoTet al. Contribution of cationic amino acids toward the inhibition of arg-specific cysteine proteinase (arg-gingipain) by the antimicrobial dodecapeptide, CL(14-25), from rice protein. Biopolymers Peptide Sci Sect. (2014) 102:379–89. doi: 10.1002/bip.22525,

25、CL (K25A)

单字母 H2N-RRLMAAKAESRA-OH

多字母 H2N-Arg-Arg-Leu-Met-Ala-Ala-Lys-Ala-Glu-Ser-Arg-Ala-OH

氨基酸个数 12

分子式 C55H102N22O16S1

平均分子量(MW) 1359.6

26、KR-12-a5

单字母 H2N-KRIVKLILKWLR-CONH2

多字母 H2N-Lys-Arg-Ile-Val-Lys-Leu-Ile-Leu-Lys-Trp-Leu-Arg-CONH2

氨基酸个数 12

分子式 C76H137N23O12

平均分子量(MW) 1565.05

参考文献：CaiaffaKSdos SantosVRAbunaGFSantos-FilhoNACilliEMSakaiVTet al. Cytocompatibility and synergy of EGCG and cationic peptides against Bacteria related to endodontic infections, in planktonic and biofilm conditions. Probiotics Antimicrob Proteins. (2021) 13:1808–19. doi: 10.1007/s12602-021-09830-3,

27、PAC-525

单字母 Ac-KWRRWVRWI-CONH2

多字母 Ac-Lys-Trp-Arg-Arg-Trp-Val-Arg-Trp-Ile-CONH2

氨基酸个数 9

分子式 C70H103O10N23

平均分子量(MW) 1426.71

参考文献：LiJYWangXJWangLNYingXXRenXLiuHYet al. High in vitro antibacterial activity of Pac-525 against Porphyromonas gingivalis biofilms cultured on titanium. Biomed Res Int. (2015) 2015:909870. doi: 10.1155/2015/909870,

28、KN-17

单字母 H2N-KWKVFKKIEKMGRNIRN-OH

多字母 H2N-Lys-Trp-Lys-Val-Phe-Lys-Lys-Ile-Glu-Lys-Met-Gly-Arg-Asn-Ile-Arg-Asn-OH

氨基酸个数 17

分子式 C99H167N31O22S1

平均分子量(MW) 2175.64

参考文献：ZhangQYuSHuMLiuZYuPLiCet al. Antibacterial and anti-inflammatory properties of peptide KN-17. Microorganisms. (2022) 10:2114. doi: 10.3390/microorganisms10112114,

29、PGLa-AM1

单字母 H2N-GMASKAGSVLGKVAKVALKAAL-CONH2

多字母 H2N-Gly-Met-Ala-Ser-Lys-Ala-Gly-Ser-Val-Leu-Gly-Lys-Val-Ala-Lys-Val-Ala-Leu-Lys-Ala-Ala-Leu-CONH2

氨基酸个数 22

分子式 C92H169N27O24S1

平均分子量(MW) 2069.56

参考文献：McLeanDTFMcCruddenMTCLindenGJIrwinCRConlonJMLundyFT. Antimicrobial and immunomodulatory properties of PGLa-AM1, CPF-AM1, and magainin-AM1: potent activity against oral pathogens. Regul Pept. (2014) 194–195:63–8. doi: 10.1016/j.regpep.2014.11.002,

30、Magainin-AM1

单字母 H2N-GIKEFAHSLGKFGKAFVGGILNQ-OH

多字母 H2N-Gly-Ile-Lys-Glu-Phe-Ala-His-Ser-Leu-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Gly-Ile-Leu-Asn-Gln-OH

氨基酸个数 23

分子式 C113H176N30O29

平均分子量(MW) 2418.79

31、SMAP-28

单字母 H2N-RGLRRLGRKIAHGVKKYGPTVLRIIRIA-CONH2

多字母 H2N-Arg-Gly-Leu-Arg-Arg-Leu-Gly-Arg-Lys-Ile-Ala-His-Gly-Val-Lys-Lys-Tyr-Gly-Pro-Thr-Val-Leu-Arg-Ile-Ile-Arg-Ile-Ala-CONH2

氨基酸个数 28

分子式 C144H258N52O30

平均分子量(MW) 3197.92

参考文献：WeistrofferPLJolySSrikanthaRTackBFBrogdenKAGuthmillerJM. SMAP29 congeners demonstrate activity against oral bacteria and reduced toxicity against oral keratinocytes. Oral Microbiol Immunol. (2008) 23:89–95. doi: 10.1111/j.1399-302X.2007.00389.x,

32、SMAP-29

单字母 H2N-RGLRRLGRKIAHGVKKYGPTVLRIIRIAG-OH

多字母 H2N-Arg-Gly-Leu-Arg-Arg-Leu-Gly-Arg-Lys-Ile-Ala-His-Gly-Val-Lys-Lys-Tyr-Gly-Pro-Thr-Val-Leu-Arg-Ile-Ile-Arg-Ile-Ala-Gly-OH

氨基酸个数 29

分子式 C146H260N52O32

平均分子量(MW) 3255.96

参考文献：GuthmillerJMVargasKGSrikanthaRSchombergLLWeistrofferPLMcCrayJet al. Susceptibilities of oral bacteria and yeast to mammalian cathelicidins. Antimicrob Agents Chemother. (2001) 45:3216–9. doi: 10.1128/aac.45.11.3216-3219.2001,

33、WLBU2

单字母 H2N-RRWVRRVRRWVRRVVRVVRRWVRR-OH

多字母 H2N-Arg-Arg-Trp-Val-Arg-Arg-Val-Arg-Arg-Trp-Val-Arg-Arg-Val-Val-Arg-Val-Val-Arg-Arg-Trp-Val-Arg-Arg-OH

氨基酸个数 24

分子式 C151H260N66O25

平均分子量(MW) 3400.11

参考文献：NovakKFDiamondWJKirakoduSPeyyalaRAndersonKWMontelaroRCet al. Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria. Antimicrob Agents Chemother. (2007) 51:1837–9. doi: 10.1128/AAC.00924-06,

34、KSL

单字母 H2N-KKVVFKVKFK-CONH2

多字母 H2N-Lys-Lys-Val-Val-Phe-Lys-Val-Lys-Phe-Lys-CONH2

氨基酸个数 10

分子式 C63H108N16O10

平均分子量(MW) 1249.63

参考文献：LiuYWangLZhouXHuSZhangSWuH. Effect of the antimicrobial decapeptide KSL on the growth of oral pathogens and Streptococcus mutans biofilm. Int J Antimicrob Agents. (2011) 37:33–8. doi: 10.1016/j.ijantimicag.2010.08.014,

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