256447-08-2
2025/2/7 17:26:41
Ac2-12 是一种膜联蛋白/脂皮质激素 1 (LC1) 模拟肽，可抑制嗜中性白细胞的外渗。Ac2-12 具有抗迁移作用，并在实验性炎症模型中抑制嗜中性白细胞的募集。
Ac2-12 (i.v.; 6.7 mg/kg, ≈70 nmol per mouse), was found to mimic the actions of lipocortin 1 (LC1) and Ac2-26 in male Swiss Albino mice (10-15 g)[1].
Ac2-12 (100 μg) significantly reduces polymorphonuclear leukocyte (PMN) influx in wild-type C57BL/6 mice and is no longer active in FPR KO mice[2].
单字母Ac-AMVSEFLKQAW-OH
CAS No. : 256447-08-2
多字母 Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-OH
氨基酸个数 11
分子式 C63H94O17N14S1
平均分子量(MW) 1351.57
精确分子量(Exact Mass)(MW) 1350.66
等电点(PI) 7.46
pH=7.0时的净电荷数 -
GRAVY 0.34
亲水残基比例 -
消光系数 5500
溶解建议疏水
参考文献：
M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158(6):1969-73. 【DOI: 10.1016/S0002-9440(10)64667-6】
