独特的Thr15氨基酸残基发生O-糖基化,增强了对革兰氏阴性菌的抗菌活性。盐会影响其活性。莱博辛能增加囊泡的通透性,并可能与天蚕素D协同作用。更新于2009年12月。莱博辛4具有抗菌活性。莱博辛4在家蚕(Bombyxmori)中被发现。
The unique Thr15 residue is O-glycosylated and enhances antibacterial activity against Gram-negative bacteria. Salts influences its activity. Lebocins increase vesicle permeability and may work synergistically with cecropin D. Updated 12/2009. Lebocin 4 has Antibacterial activity. Lebocin 4 was found in silk moth, Bombyx mori.
单字母 H2N-DLRFWNPREKLPLPTLPPFNPKPIYIDMGNRY-OH
多字母 H2N-Asp-Leu-Arg-Phe-Trp-Asn-Pro-Arg-Glu-Lys-Leu-Pro-Leu-Pro-Thr-Leu-Pro-Pro-Phe-Asn-Pro-Lys-Pro-Ile-Tyr-Ile-Asp-Met-Gly-Asn-Arg-Tyr-OH
氨基酸个数 32
分子式 C184H277N47O45S1
平均分子量(MW) 3899.52
精确分子量(Exact Mass)(MW) 3897.06
等电点(PI) 11.61
pH=7.0时的净电荷数 4.98
GRAVY -0.8
亲水残基比例 0.06
消光系数 8480
溶解建议 疏水
参考文献:
Rao XJ, Xu XX, Yu XQ. Functional analysis of two lebocin-related proteins from Manduca sexta. Insect Biochem Mol Biol. 2012;42(4):231-239. doi:10.1016/j.ibmb.2011.12.005