KEMPFPKYPVEP 是一种从消化酪蛋白中筛选出的肽，具有改善失忆小鼠模型空间记忆的能力。KEMPFPKYPVEP 肽被发现能够防止东莨菪碱诱导的短期空间记忆缺陷，并能增强正常小鼠的长期物体识别记忆，同时在额叶皮质中发现多巴胺和去甲肾上腺素水平升高，但血清素水平未见变化。此前的流行病学调查表明，食用乳制品可以预防认知能力下降，然而只有用真菌发酵的奶酪才含有 KEMPFPKYPVEP 肽，其中卡芒贝尔奶酪中的含量最高，为每克 14.58 至 39.02 皮摩尔。

KEMPFPKYPVEP is a peptide identified from a screen of digested casein protein for the ability to improve spatial memory in amnesia mouse models. KEMPFPKYPVEP peptide was found to prevent scopolamine induced deficit in short term spatial memory, and also enhance long term object recognition memory in intact mice, with increased levels of dopamine and norepinephrine, but not serotonin being found in the frontal cortex. Previous epidemiological investigations have indicated that consuming dairy products can prevent cognitive decline, however only cheese fermented with fungi contains the KEMPFPKYPVEP peptide, which is found at the highest level in Camembert at 14.58-39.02 pmol per gram.

单字母 H2N-KEMPFPKYPVEP-OH
多字母 H2N-Lys-Glu-Met-Pro-Phe-Pro-Lys-Tyr-Pro-Val-Glu-Pro-OH
氨基酸个数 12
分子式 C70H104N14O18S1
平均分子量(MW) 1461.72
精确分子量(Exact Mass)(MW) 1460.74
等电点(PI) 10.25
pH=7.0时的净电荷数 1.98
GRAVY -1.1
亲水残基比例 -
消光系数 1490
溶解建议 亲水

参考文献：
Ano et al (2019) Identification of a Novel Peptide from β-Casein That Enhances Spatial and Object Recognition Memory in Mice. J Agric Food Chem. 67(29) 8160 PMID: 31241932