ACT1（α-连接蛋白羧基末端）是一种膜通透性肽，包含 Cx43 CT 的最后九个氨基酸，并与触角蛋白内化序列（RQPKIWFPNRRKPWKKRPRPDDLEI）相连。研究表明，ACT1 能够加速小鼠皮肤创伤的愈合，增强表皮复杂性，减少肉芽组织面积，并提高皮肤的断裂强度和延展性，这表明 Cx43 CT 肽 ACT1 能够促进皮肤创伤的再生性愈合。该肽可能在皮肤以外的组织中也有应用，包括心脏、角膜和脊髓。

ACT1 (α–connexin carboxyl-terminal) is a membrane-permeant peptide incorporating the last nine amino acids of the Cx43 CT, and it is linked to an antennapedia internalization sequence (RQPKIWFPNRRKPWKKRPRPDDLEI). ACT1 is shown to accelerate wound closure, enhance epidermal complexity, reduce granulation tissue area and increase breaking strength and extensibility of skin following cutaneous wounding in mice, which indicates that the Cx43 CT-peptide ACT1 promotes regenerative healing of cutaneous wounds. The peptide may have applications in tissues other than skin, including heart, cornea and spinal cord.

单字母 H2N-RQPKIWFPNRRKPWKKRPRPDDLEI-OH
多字母 H2N-Arg-Gln-Pro-Lys-Ile-Trp-Phe-Pro-Asn-Arg-Arg-Lys-Pro-Trp-Lys-Lys-Arg-Pro-Arg-Pro-Asp-Asp-Leu-Glu-Ile-OH
氨基酸个数 25
分子式 C150H238N48O34
平均分子量(MW) 3257.8
精确分子量(Exact Mass)(MW) 3255.84
等电点(PI) 12.37
pH=7.0时的净电荷数 6.98
GRAVY -1.99
亲水残基比例 0.07
消光系数 11000
溶解建议 亲水

参考文献：
Ghatnekar GS, O'Quinn MP, Jourdan LJ, Gurjarpadhye AA, Draughn RL, Gourdie RG. Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding. Regen Med. 2009 Mar;4(2):205-23. doi: 10.2217/17460751.4.2.205. PMID: 19317641; PMCID: PMC2720252.